GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs9815354 | 1 | rs3934103 | chr3:41977214 | ULK4 | chr3:41288091-42003660:- | -0.4 | -4.64 | 7.41E-6 | Diastolic blood pressure |
| UCEC | cis | rs9894429 | 1 | rs3935543 | chr17:79579874 | TSPAN10 | chr17:79609349-79615778:+ | 0.66 | 8.57 | 1.11E-14 | Eye color traits |
| UCEC | cis | rs2028299 | 1 | rs3960018 | chr15:90383307 | AP3S2 | chr15:90373832-90456222:- | -0.51 | -5.05 | 1.26E-6 | Type 2 diabetes |
| UCEC | cis | rs39841 | 1 | rs39841 | chr5:96120170 | ERAP1 | chr5:96096515-96149837:- | -0.47 | -5.12 | 9.28E-7 | Inflammatory skin disease |
| UCEC | cis | rs9894429 | 1 | rs4074915 | chr17:79579230 | TSPAN10 | chr17:79609349-79615778:+ | -0.66 | -8.39 | 3.16E-14 | Eye color traits |
| UCEC | cis | rs9894429 | 1 | rs4074916 | chr17:79579248 | TSPAN10 | chr17:79609349-79615778:+ | -0.66 | -8.57 | 1.11E-14 | Eye color traits |
| UCEC | cis | rs9473555 | 1 | rs4267943 | chr6:49439805 | MUT | chr6:49398994-49431031:- | -0.33 | -5.41 | 2.38E-7 | Folate pathway vitamin levels |
| UCEC | cis | rs10935120 | 1 | rs4309773 | chr3:134277301 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.62 | 8.3E-6 | Height |
| UCEC | cis | rs10461617 | 1 | rs43184 | chr5:56141777 | C5orf35 | chr5:56205103-56213010:+ | 0.63 | 6.87 | 1.51E-10 | Type 2 diabetes |
| UCEC | cis | rs10935120 | 1 | rs4367113 | chr3:134287975 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 4.38 | 2.19E-5 | Height |
| UCEC | cis | rs10935120 | 1 | rs4417907 | chr3:134291363 | ANAPC13 | chr3:134196547-134204865:- | 0.41 | 4.72 | 5.28E-6 | Height |
| UCEC | cis | rs9473555 | 1 | rs4469291 | chr6:49440614 | MUT | chr6:49398994-49431031:- | 0.34 | 5.77 | 4.4E-8 | Folate pathway vitamin levels |
| UCEC | cis | rs60843830 | 1 | rs4497901 | chr2:239969 | SH3YL1 | chr2:218138-264810:- | -0.42 | -5.95 | 1.81E-8 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs4660306 | 1 | rs4660306 | chr1:45978675 | CCDC163P | chr1:45960581-45965646:- | 0.57 | 7.27 | 1.74E-11 | Homocysteine levels |
| UCEC | cis | rs4660306 | 1 | rs4660870 | chr1:45995231 | CCDC163P | chr1:45960581-45965646:- | -0.47 | -6.19 | 5.35E-9 | Homocysteine levels |